Zhongke Medicine (Shenzhen) Co., Ltd. & Shenzhen Zhongke Ruizhi Diabetes Research Institute

Zhongke Medicine (Shenzhen) Co., Ltd. together with Shenzhen Zhongke Ruizhi Diabetes Research Institute is a high-tech enterprise focusing on chronic disease prevention and treatment as well as health product R&D, located in the National Science and Technology Business Incubation Base of Shenzhen. The institution has gathered a professional R&D team of 462 people, among which 85% hold senior professional titles, including more than 30 experts who enjoy the State Council Special Allowance. For years, we have been deeply engaged in the fields of biotechnology, traditional Chinese medicine, and health product R&D, committed to the innovation and transformation of cutting-edge biotechnologies. Our related technologies and products have covered more than 20 provinces and regions in China and 7 overseas countries, providing professional rehabilitation solutions for chronic disease patients around the world.

At present, the incidence of chronic diseases in China is continuously rising. Taking diabetes as an example, the number of diabetic patients in China has grown rapidly from 92 million in 2008, and it is expected to exceed 400 million by 2025. The annual number of new patients reaches 5.5 million, with an average of 10 new cases every minute, and 1 million people lose their lives due to diabetes and its complications every year. The traditional chronic disease treatment model has never been able to break the limitation of "lifelong medication", and the technical achievements of Zhongke Medicine are precisely aimed at this huge social health demand, bringing a brand-new rehabilitation possibility for chronic disease patients.

Core Expert Team

The core leader of the institution, Academician Mei Lianwu, is an academician of the European Academy of Natural Sciences. He also serves as a researcher at the Chinese Academy of Sciences in the United States, visiting professor at many internationally renowned universities including University of Bolton, Heluo Medical University of the United States, and International Medical University of Sri Lanka, as well as the Sino-British Cultural Health Ambassador and International Health Ambassador.

Meanwhile, he also holds social positions such as the Dean of the Institute of Traditional Chinese Medicine for Chronic Disease Prevention, Expert Member of the Traditional Chinese Medicine Society of China, First Review Expert of Academic Projects of the Guangdong Provincial Association for Science and Technology, Vice President of Shenzhen Health Care Science and Technology Society, and Expert of Shenzhen Community Health Science Promotion Group. He has 35 years of research experience in diabetes, gout, and chronic disease prevention and treatment.

In terms of scientific research achievements, Academician Mei Lianwu has obtained nearly 200 patent achievements and more than 200 proprietary technical achievements, covering multiple chronic disease and health fields such as diabetes, hypertension, gout, thyroid diseases, Alzheimer's disease, autism, and male health issues. Among them, there are many national invention patents including "A medicine for regulating diabetes, hypertension and hyperlipidemia", "A medicine for preventing and treating gout and hyperuricemia", "A medicine for eye diseases", "A medicine for treating impotence, premature ejaculation and sexual dysfunction", covering various common health problems of the public.

In the academic field, Academician Mei Lianwu has been invited to participate in many international and domestic academic forums on traditional Chinese medicine, published many academic papers, and participated in writing more than ten international and domestic academic works including MEDICINA ALTERNATIVA ANNIVERSARY 1962-2017, Worad congress of Integrated Medicines, Proceedings of the Chinese Medicine Delegation of the 55th World Congress of Traditional Medicine, Chinese Famous Traditional Chinese Medicine Doctors, Pioneer Ceremony of Chinese Doctors. He has won many honors such as the Lifetime Achievement Award of the University of Sri Lanka, the Science and Technology Model of the China Scientists Forum, and the Gold Award of the Shenzhen International Bio-life Health Industry Exhibition. He is the drafter and founder of the self-healing standard for type 2 diabetes, promoting the industry standardization development in the field of chronic disease self-healing.

Core Business and Technical Achievements

The core technology research and development of Zhongke Medicine started in 1989. After nearly 40 years of continuous iteration, we have completed the upgrade of three generations of technologies: we launched the first generation of core products in 2009, completed the clinical verification of the second generation of technology in 2013, finished the mature implementation of the third generation of technology in 2016, and officially launched the market promotion in 2017. With the accumulation of nearly 40 years, we have created the industry-leading Type 2 Diabetes Self-healing Rehabilitation System, completely breaking the limitation of lifelong medication in traditional diabetes treatment.

For a long time, the traditional diabetes treatment has adopted the internationally accepted "Five Carriages" model, namely blood glucose monitoring, diabetes education, diet control, exercise therapy, and drug treatment. This model can only achieve temporary control of blood glucose, unable to solve the root problem of damaged pancreatic islet cells, leading to the need for patients to take medicine for life, and long-term medication will also bring side effects such as liver and kidney damage. The self-healing rehabilitation system of Zhongke solves this problem from the root:

• The core product "Meitang" is a food-grade traditional Chinese medicine preparation of homology of medicine and food, containing no western medicine ingredients. Different from the logic of traditional hypoglycemic drugs that only "pack away blood glucose" — traditional hypoglycemic drugs can only temporarily reduce blood glucose indicators, but cannot solve the core problem of cell hunger. As a cell repair agent, Meitang repairs the islet function from the root through the three-stage scientific mechanism of "Regulation, Nourishment, Regeneration".

Detailed Explanation of the Three-stage Self-healing Mechanism

1. Regulation: Repair the living environment, the premise of self-healing
Aiming at the core problem of visceral function disorder in diabetic patients, the institution starts with adjusting diet, living habits and physical fitness, gradually repairing the patient's spleen and stomach transportation function, solving the problems of liver-spleen disharmony and unsmooth nutrition transmission, opening up the body's circulatory system, restoring the living environment of insulin, eliminating the inducing factors of diabetes from the root, and laying the foundation for subsequent cell repair.

2. Nourishment: Repair damaged cells, the foundation of self-healing
Through the unique nutritional ingredients of Meitang, we provide sufficient exclusive nutrition for pancreatic islet cells, help the damaged pancreatic islet cells complete self-repair, and at the same time activate the dormant pancreatic islet cells in the body, wake up their reproductive ability, so that the number of pancreatic islet cells can gradually recover from hundreds of thousands to the normal level of millions, so that the pancreas can regain the normal insulin secretion ability.

3. Regeneration: Restore metabolic balance, the goal of rehabilitation
When the islet function is restored, the system will further help patients adjust various physical indicators, helping weight, blood lipid, cholesterol, high-density lipoprotein, low-density lipoprotein and other metabolic indicators gradually return to normal levels, so that the entire metabolic system of the body can return to normal, achieving real self-healing, not just temporary normal indicators.

The system is equipped with a complete rehabilitation standard, ensuring the rehabilitation effect through the whole-process monitoring of 7 core indicators including fasting blood glucose, postprandial blood glucose, glycosylated hemoglobin, C-peptide, blood lipid, and cholesterol. Clinical data has verified the effectiveness of the system: compared with traditional insulin treatment, insulin can only temporarily control blood glucose, and blood glucose will rebound rapidly after stopping the drug; while through the Meitang system conditioning, 20 days after taking the drug, the insulin resistance of patients will be significantly weakened, and within 3-6 months, the islet cells can recover to the normal level of 1.5-2 million units. Blood glucose will gradually stabilize and return to the normal range, and can remain stable after stopping the drug, truly achieving the self-healing of diabetes. The related technology has obtained the national invention patent.

In addition, the institution has also built a health product matrix covering all categories of chronic diseases, developing more than ten professional products for different health needs:

• Honeysuckle Oyster Pill for diabetes, helping type 2 diabetic patients achieve self-healing rehabilitation;

• Jinyu Pill for gout, helping gout patients regulate uric acid and solve gout problems;

• Orange Peel Kelp Pill for thyroid diseases (hyperthyroidism, hypothyroidism, nodules, tumors, etc.), covering various thyroid health problems;

• Ningling Element Ganoderma Lucidum and Sesame Pill for anti-aging needs, helping customers achieve scientific anti-aging;

• Ginseng Cordyceps Black Pill for sleep conditioning, improving sleep quality and regulating body state;

• Oligopeptide Anti-wrinkle Essence for beauty and anti-wrinkle, achieving skin anti-wrinkle and rejuvenation;

• Shencao Bian Pill for male health, regulating male physical state;

• Ginseng Dendrobium Black Pill for dysmenorrhea, improving women's menstrual health;

• Renfa Essence for anti-hair loss and hair growth, solving hair loss problems;

• Shixing Tianxia Eye Essence for eye health, improving eye health status.

For core chronic disease products, the institution has also launched a rare contract guarantee service in the industry. For core categories such as diabetes, gout, and thyroid diseases, we can provide a contract service of refund if invalid, to protect users' health with strong technical confidence, which is also the embodiment of the institution's high recognition of its own technical achievements.

Bailinghui Global Medical Access

Based in Shenzhen, Bailinghui is a professional institution focusing on providing systematic, personalized and full-cycle health management services for high-net-worth families and elites. With the core mission of "Scientific Anti-aging, Quality Longevity", relying on the self-operated Shenzhen Bailing Traditional Chinese Medicine Hospital and Integrated Medicine Center, we integrate the global cutting-edge achievements of longevity medicine with local high-end medical and traditional Chinese medicine wisdom, helping customers achieve a quality life of 120 years old.

Original Health Management System

Based on decades of in-depth research on longevity medicine, Bailinghui has created a complete theoretical framework of health management, providing solid theoretical support for full-cycle health services, breaking the fragmentation limitation of traditional health management:

1. Three Pillars of Life
The institution proposes that the core of longevity is not a single indicator adjustment, but the systematic strengthening of the core system of life, specifically including:

￮ Skeleton and joints (Steel Frame Structure) as the basic framework of life: supporting all life activities of the human body, which is the foundation of health;

￮ Blood vessel circulation (Core Pipeline) as the channel for nutrient metabolism: maintaining the nutrient delivery and metabolic waste discharge of the body, which is the "lifeline" of the body;

￮ Immune defense (Security System) as the health barrier: resisting external bacterial infections, removing aging and mutated cells in the body, which is the health protection barrier.
Through the systematic strengthening of these three systems, we can build a solid foundation of health from the root and delay the aging process.

2. Three-in-one Health Architecture
The institution integrates the advantages of traditional Chinese and western medicine, creating a three-dimensional intervention system, achieving the fusion effect of 1+1>2:

￮ Vitality (Traditional Chinese Medicine Consolidation): Centered on the traditional Chinese medicine system, through physical condition differentiation, ointment, pills, traditional Chinese medicine, acupuncture and other traditional means, conditioning the body's state as a whole, building a solid health foundation;

￮ Regeneration (Regenerative Rejuvenation): Applying international cutting-edge regenerative medicine technology, stimulating the body's self-repair ability at the genetic and cellular level, achieving the reversal of aging;

￮ Precision (Precision Optimization): Based on modern functional medicine and genomics, achieving ultra-early risk insight of diseases, carrying out targeted intervention for problems, achieving precise health management.

Based on this complete theory, the institution has built a two-wheel drive service model of "Family Private Doctor Consulting Service System" and "Longevity Anti-aging Science System", covering all scenario needs from daily health management to in-depth anti-aging intervention, providing full-dimensional health protection for customers.

Family Private Doctor Consulting Service

For the health needs of high-net-worth families and clans, Bailinghui has created an exclusive family private doctor service, equipped with an exclusive service group of "Family Chief Health Officer + Health Butler + Multidisciplinary Expert Team", providing the whole family with the whole-process exclusive service, achieving cross-generational health protection:

• The service content covers health file establishment, daily health consultation, active medical coordination, major disease defense and global medical resource docking. It not only covers the current family members, but also covers the whole age range of children, adolescents, middle-aged and elderly people, achieving full-cycle health management from core families to cross-generational clans.

• The institution has created the exclusive "Family Five-dimensional Immunity Therapy", systematically improving the immunity of the whole family from the five dimensions of spirit, nutrition, behavior, regeneration, and traditional prescription, not only solving the health problems of individual members, but also protecting the long-term health of the whole family.

Longevity Anti-aging Science System

For customers' anti-aging and longevity needs, Bailinghui has created a whole-process standardized anti-aging intervention system, achieving quantifiable and traceable anti-aging:

1. Comprehensive Precision Assessment: First, through biological age detection, multi-omics analysis, system function assessment and lifestyle assessment, we establish an exclusive personal health baseline for customers, accurately quantify the customer's aging process, and find the core problems of aging.

2. Personalized Intervention Plan: Based on the assessment results, combined with aging protectants, targeted nutrition, regenerative medicine and customized lifestyle reshaping, we create an exclusive anti-aging intervention plan for customers, achieving personalized service of one plan for one person.

3. Whole-process Dynamic Management: During the intervention process, through regular re-examination and data tracking, we monitor the customer's health status in real time, dynamically adjust the intervention plan, ensure the sustainability of the anti-aging effect, and avoid the rigidity of the plan.

For different anti-aging needs, the institution has also created a layered longevity anti-aging special plan to meet the needs of different customers:

• Basic Assessment Plan: Establish a basic health baseline for customers, complete basic health assessment, and provide a basis for subsequent health management;

• In-depth Optimization Plan: On the basis of basic assessment, add in-depth assessment of multi-omics and biological age, achieve more accurate aging quantification, and provide more in-depth intervention plans;

• Full-cycle Supreme Plan: Cover the whole-process service of comprehensive assessment, annual re-examination, exclusive butler, and global resource docking, providing one-stop full-cycle anti-aging management service for top high-net-worth customers.

In addition, the institution has also created five core health management star products, covering precision physical examination, longevity anti-aging vitality therapy, chronic disease management, menopause comprehensive management, bone health management, tumor prevention management, children's growth and development management and other fields, meeting the diversified health needs of different groups of people.

High-end Precision Testing Services

To achieve accurate health assessment, Bailinghui has introduced a series of international cutting-edge precision testing technologies, built a full-dimensional high-end testing system, providing support for precise health management:

• Whole Genome Testing: It can cover more than 800 congenital genetic diseases, more than 60 common diseases and tumors, and more than 100 personalized medication guidance. It can not only achieve ultra-early prevention of diseases, but also provide personalized health guidance for customers, and even help customers trace the origin of their families and understand the health history of their families.

• Helium-free "007" Magnetic Resonance Testing: The first such advanced equipment in Shenzhen, it can achieve non-invasive and radiation-free integrated screening of systemic blood vessels, complete portal vein imaging without injection, and complete disease screening of cerebral blood vessels, coronary arteries and abdominal large blood vessels at the same time. At the same time, it is equipped with whole-body compressed sensing technology, which has faster scanning speed and higher image resolution, can detect tiny lesions in the early stage, and set a new benchmark for high-end health screening.

• NAD+ Testing: By detecting the level of NAD+ in the body, we can evaluate the cell's energy metabolism state, aging state and mitochondrial function, providing a core scientific basis for the formulation of anti-aging programs.

• ctDNA Tumor Early Screening: By detecting circulating tumor genes in the blood, we can achieve ultra-early screening of tumors, find risks in the early stage of tumors, and achieve early prevention and early intervention.

• Children's Talent Gene Testing: Detect the eight intelligences of children, help parents understand their children's talent characteristics, and provide a scientific basis for children's training, achieving teaching students in accordance with their aptitude.

• Brain Health Testing: Cover the full-dimensional detection of the brain's structure, function, blood supply and nerve state, early detect problems such as cerebral infarction, brain atrophy, cognitive decline, and protect brain health.

• In addition, the institution also provides dozens of high-end testing projects such as hormone testing, bone metabolism testing, immune function testing, allergy testing, antioxidant vitamin testing, covering the full-dimensional needs from disease early screening to anti-aging assessment, laying a solid foundation for precise health management.

To meet the physical examination needs of different customers, the institution has also created layered medical examination packages:

• Basic Package C: Including 23 basic examinations, covering conventional blood and urine routine, liver and kidney function, blood lipid and blood glucose, basic imaging examinations, etc., suitable for daily basic health screening;

• Mid-end Package B: On the basis of basic examinations, add more biochemical and tumor marker detection, suitable for customers with certain health management needs;

• High-end Package A: Cover comprehensive biochemical, tumor marker, and imaging examinations, including TCT, HPV, chest CT, brain CT and other in-depth examinations, suitable for in-depth annual health physical examination.

Core Advantages and Service Scenarios

With a complete system and resources, Bailinghui has created an industry-leading high-end health service capability, providing customers with top-level health management experience:

• Entity Medical Support: The institution independently operates Shenzhen Bailing Traditional Chinese Medicine Hospital and Integrated Medicine Center, has compliant offline diagnosis and treatment places and professional execution team, all services are supported by entity medical care, ensuring the professionalism and compliance of services, different from ordinary lightweight health management institutions.

• Integrated Innovation of Chinese and Western Medicine: The institution is not simply a traditional Chinese medicine or western medicine service, but realizes the deep integration of Chinese and western medicine. It uses western medicine's precision detection to find problems, and uses traditional Chinese medicine's overall conditioning and regenerative medicine intervention to solve problems, achieving the effect of 1+1>2, which is also the core innovation advantage of the institution.

• Scientific Research and Technology Leadership: The institution always connects with the global cutting-edge achievements of longevity medicine, transforms the latest scientific research achievements into evidence-based clinical practice, and at the same time uses AI analysis, digital platform and wearable devices to achieve precise health monitoring and management, making health management more intelligent and precise.

• Global Medical Resource Network: The institution links the top three hospitals in the Guangdong-Hong Kong-Macao Greater Bay Area, top overseas hospitals and global Chinese and western medicine expert resources, can connect customers with global high-end medical resources, meeting customers' diversified medical needs.

• Private and Exclusive Service: The institution provides customers with one-on-one health butler, multi-to-one expert team exclusive service, protects customers' privacy throughout the cycle, creates a private and exclusive high-end health experience, meeting the privacy needs of high-net-worth customers.

In terms of service scenarios, Bailinghui can provide multi-scenario service coverage to meet customers' different needs:

• On-site door-to-door service in Shenzhen, including family/enterprise health screening, personal trainer guidance, nutrition delivery, allowing customers to enjoy professional health services without leaving home;

• Remote health management, supporting online consultation, data tracking, program adjustment, even if customers are not in Shenzhen, they can also enjoy the whole-process health management service;

• Overseas health trip, the institution links with international longevity clinics, providing customers with overseas in-depth anti-aging experience, meeting customers' high-end experience needs.